Zunich-Kaye syndrome is also known as Zunich neuroectodermal syndrome. It is a unique congenital ichthyosis first described in 1983. It is also allude to as CHIME disorder. It is a hereditary syndrome with only a scarce cases studied and published. Zunich-Kaye syndrome has an autosomal retreating pattern of inheritance.


Symptoms that may be proposed comprise characteristic facies, hearing loss, and cleft palate. Related symptoms range from things such as heart defects, colobomas of the eyes, mental retardation, ichthyosiform dermatosis, and ear abnormalities.



Treatment with isotretinoin may induce substantial resolution of skin lesions, but the risk of secondary infection remains.


Inspect or observe the entire skin surface. Observe the overall pattern of skin lesions, and record their position. Notice their color, shape, and size. Inspect the tissue of his mouth, nose, and lips and inspect his ears, hair, and nails.